# ctrdata 1.22.1

## Bug fix
- Adapt testing after SQLite 3.48.0 (in RSQLite 2.3.10 since 2025-05-02) accepts now up to 1000 arguments
- Fixed EUCTR conversion to `NDJSON` in Javascript for rare specific trial(s), thanks @machado-t (#45)
- Revised `dbFindIdsUniqueTrials()` to work with more than 80,000 records, thanks @machado-t (#48)

## Internal
- Modify internal function `.dbMapIdsTrials()` to use both CTIS1 and CTIS2 field names, and defer de-duplication to parent function

# ctrdata 1.22.0

## Improvements
- When using `querytoupdate` for CTIS, set `ctishistory = TRUE` to create historic versions from previously downloaded trial record, see `vignette("ctrdata_summarise")`
- Trial concept `f.trialObjectives()` improved with structured data from CTIS and EUCTR
- `ctrGenerateQueries()` now defaults to interventional trials with medicines
- `ctrGenerateQueries()` additionally provides a CTGOV expert search query
- `ctrGenerateQueries()` now also covers countries of trial conduct 

## Bug fix
- Fixed for `ISRCTN` API term mangling
- Fixed digesting marginal cases in notifications in `f.statusRecruitment()`
- Fixed `ctrGenerateQueries` to handle 'or' as needed for certain filters

# ctrdata 1.21.1

## Bug fix 
- Fixed all `f...` clinical trial concept functions to handle NAs, included in testing
- Fixed round brackets for nesting logical operators in `queryterm`, thanks @jacksknnr (#46)
- Fixed CRAN NOTE on package size

# ctrdata 1.21.0

## Improvements
- New feature: built-in functions that implement and calculate common trial concepts across different registers, see `help("ctrdata-trial-concepts")` which should largely avoid that users have to code themselves and repeatedly common trial concepts, such as recruitment start date, trial investigating a medicine as intervention, trial being a platform trial etc. 
- New feature: function `ctrGenerateQueries()` to search all registers from a user's single input, e.g. intervention, phase, dates
- Refactored `dfMergeVariablesRelevel()`, factored out returning data frame or tibble, thanks @machado-t (#45)

## Bug fix
- `dbFindIdsUniqueTrials()` excludes GB records from `EUCTR` whenever there is at least one Member State or Third country record
- `EUCTR` no longer allows to search for the status of a clinical trial, adapted testing to it
- Correct `ctrShowOneTrial()` and `ctrLoadQueryIntoDb()` for certain EUCTR trials
- Early stopping if database collection is read-only
- Added typing of fields newly appearing in CTIS
- Documentation simplification and update
- Changing vignettes from PDF to HTML

# ctrdata 1.20.0

## Improvements
- New function `ctrShowOneTrial()` to inspect a trial structure and data, and to select fields for `dbGetFieldsIntoDf()`; in this context, make `ctrGetQueryUrl()` work for identifiers of single trials
- Improve and update documentation

## Bug fix
- Refactor `dfTrials2Long` to correct generating identifiers for single-item groups
- Correct using certain testing conditions

# ctrdata 1.19.5

## Improvements
- Refactored `dbFindFields()` for speed and efficiency
- Adapted to newly available expert search in `CTGOV2`

## Bug fix
- Correct `CTGOV2` endpoint for document downloads
- Adapted to `curl` v6 having renamed the timeout parameter
- Documents download (folders only for trials with documents; excluding duplicates)

# ctrdata 1.19.4

- Fix vignettes and update documentation website (pkgdown)
- Make `dbFindFields()` more robust, specify scalar search fields to identify records

# ctrdata 1.19.3

- Improve Tampermonkey script (this serves to copy searches in any register to the clipboard, and also can open a `CTIS` search from an URL, see https://rfhb.github.io/ctrdata/#id_2-script-to-automatically-copy-users-query-from-web-browser
- Refactored parts of documents downloading for handling CDN links
- Simplify code now that `CTIS` provides an advanced search 
- Code styling and linting

# ctrdata 1.19.2

## Improvements
- Added typing for newly appearing variables in `CTIS`
- Accelerated `CTIS` trial data processing

## Bug fixes
- Fix incomplete downloads from `CTIS` by disabling HTTP/2 multiplexing in another function

# ctrdata 1.19.1

## Improvements
- Revised translation of location elements from search URL to API call for `CTGOV2`

# ctrdata 1.19.0

## Possibly breaking changes
- `CTGOV` has retired on 2024-06-25 the classic website and API used by `ctrdata` since 2015. To support users, `ctrdata` now automatically translates and redirects queries to the current website. This helps with automatically updating previously loaded queries (`ctrLoadQueryIntoDb(querytoupdate = <n>)`), manually migrating queries and reproducible work on clinical trials information. This new functionality in `ctrdata` translates a user's search query URL from the classic website into a query for the current `CTGOV` website, for all search parameters. Since the structure and format of data differs between data retrieved from the current API and previously retrieved from the classic API, `ctrdata` will continue to identify the current API as `register = "CTGOV2"`, to support the analysis stage. In addition, `ctrdata` documentation continues to include examples of analyses with `CTGOV` data, as this may have been downloaded earlier. 
- `CTIS` has been relaunched on 2024-06-17, and `ctrdata` has been fully updated to it. At the moment, `CTIS` provides basic searches and no search query URL. To support users, `ctrdata` includes an updated script that extracts a user's search parameters from the register search page to the clipboard and into the browser URL bar. In addition, the script triggers a search for trials when opening such a query URL, see https://rfhb.github.io/ctrdata/#id_2-script-to-automatically-copy-users-query-from-web-browser. File names of `CTIS` documents start now with the document type, e.g. `SbjctInfaICF - L1 SIS and ICF NL for publication.pdf`, since the prefix (document source) introduced in version 1.18.0 is no more applicable. 

## Improvements 
- Reduced size of demo database in package, addressing `CRAN` notes
- Adapted `ctrFindActiveSubstanceSynonyms()` to `CTGOV2` API; this is now based on terms used in studies
- Updated vignette and added inspecting a specific trial
- Updated register information, adding caveats and issues
- Updated estimated download sizes and user information
- Avoided duplicate data and file retrievals
- New attribute `ctrdata-collection` for data frames with trial information; same content as attribute `ctrdata-table`, which will be removed by end 2024
- Split utils.R into files for functions and fields

## Bug fixes
- Correct partial date brackets for `CTGOV2`
- Disable HTTP/2 multiplexing for `CTIS`

# ctrdata 1.18.0 (2024-05-13)

## Possibly breaking change
- File names for documents downloaded from `CTIS` now include the document type and use different separators (e.g., "parts2auth - SbjctInfaICF - ..." as abbreviation of "Subject information and informed consent form (for publication)", was previously "parts2auth_...")

## Improvements 
- Add retrieval of historic versions of trial records from `CTGOV2` (automatically retrieved from `CTIS`, not available for other registers)
- Added typing of newly appearing fields from `CTIS`
- Increase testing coverage to 93.7% locally
- Added missing CI for the combination of `DuckDB` and `CTGOV2`

## Bug fixes
- Correct typing certain fields as (lists of) integers
- Handle marginal case in `dbGetFieldsIntoDf()`
- Changed `unlink` of intermediate files
- Minor vignettes corrections

# ctrdata 1.17.2 (2024-02-25)

## Bug fixes
- Switch sequence of API endpoints used with `CTIS` 
- Correct handling multiple public events with `CTIS`
- Re-use `CTIS` downloads in a given session

# ctrdata 1.17.1 (2024-02-05)

## Improvements
- Additional `CTIS` field types and possibly documents (associated clinical trials)
- Use `ctId` instead of `id` as `CTIS` top-level field (a further synonym used in the API is `clinicalTrialId`)

## Bug fixes
- Added handling of unexpected Unicode in protocol-related data from one trial in `EUCTR`
- Improved predicted download sizes and times for `EUCTR`
- Return with message if `CTIS` query did not result in any trials

# ctrdata 1.17.0 (2024-01-22)

## Possibly breaking changes
- Reimplemented `dbGetFieldsIntoDf()` to accelerate and have more predictable, simplified returns, in particular for nested fields; also attempts to recursively expand simply nested data into additional columns in the returned data frame
- Reimplemented `dbFindFields()` to accelerate; both based on improved `nodbi::docdb_query()`
- `dbFindFields()` now digests a sample of records to quickly find fields, or all records if `sample = FALSE` but taking increasing time with increasing number of records
- If using `nodbi::scr_postgres()`, parameter `fields` of `dbGetFieldsIntoDf()` is limited to less than 50 fields; a message flags for any backend potential compatibility issues, suggesting to use parent fields, e.g., `a.b` instead of `c("a.b.c.d", "a.b.c.e")`
- Parameter `stopifnodata` of `dbGetFieldsIntoDf()` is no more needed and deprecated
- Reimplemented typing fields to speed up and to simplify

## Improvements
- Register data are re-used and not downloaded again in an interactive session (that is, the same temporary folder is now re-used throughout a user's session) 
- Temporary folder can be set by users with `options(ctrdata.tempdir = "<user_specified_folder>")`
- Inform MS Windows users if `cygwin` was found so that they may chose to delete it
- Many fields added for typing e.g. as date in `dbGetFieldsIntoDf()`

## Bug fixes
- Adapted and corrected information loading to newly available data in `CTIS`
- Corrected escaping, and back-conversion, of characters in `JSON` from `CTIS`

# ctrdata 1.16.0 (2023-11-24)

## Possibly breaking changes

### XML files are converted slightly differently
- EUCTR result-related information in attributes: e.g. new: `{"id":"PostAssignmentPeriod-46349"}`, was: `{"@attributes":{"id":"PostAssignmentPeriod-46349"}}`
- Consequently, it should work to just delete `@attributes` from field names such as `dbGetFieldsIntoDf("clinical_results.baseline.analyzed_list.analyzed.count_list.count.@attributes.value", db)`
- EUCTR protocol-related information although no differences were found yet 
- CTGOV attributes of bare values remain not included in the resulting `NDJSON` (e.g., some but not all records have `<start_date type="Actual">March 15, 2004</start_date>`, and this is converted to `{"start_date":"March 15, 2004"}`)

### EUCTR: some renaming to harmonise EU and 3rd country trial fields
- new: `e83_single_site_trial`, was (EU trials): `e83_the_trial_involves_single_site_in_the_member_state_concerned`
- new: `e83_single_site_trial`, was (3rd country trials): `e83_will_this_trial_be_conducted_ at_a_single_site_globally` 
- new: `e863_trial_sites_planned_in`, was (EU trials): `e863_specify_the_regions_in_which_trial_sites_are_planned` 
- new: `e863_trial_sites_planned_in`, was (3rd country trials): `e863_specify_the_countries_outside_of_the_eea_in_which_trial_sites_are_planned` 
- new: `e84_multiple_sites_in_member_state`, was (EU trials): `e84_the_trial_involves_multiple_sites_in_the_member_state_concerned` 
- new: `e840_multiple_sites_globally`, was (3rd country trials): `e84_will_this_trial_be_conducted_at_multiple_sites_globally`

See also https://github.com/rfhb/ctrdata/issues/26#issuecomment-1749555081
  
## Bug fixes
- corrected batch iterations over CTIS trials accommodating unclear `totalSize` response
- corrected translation of some fields from the browser URL to the API call for CTGOV2 (closes https://github.com/rfhb/ctrdata/issues/32)
- corrected minimum curl version to 5.1.0 (closes https://github.com/rfhb/ctrdata/issues/31)
- handled errors when saving EUCTR results (e.g., too long file path name, closes https://github.com/rfhb/ctrdata/issues/30 and https://github.com/rfhb/ctrdata/issues/28)

## Improvements

### Major 
- **No external tools required any more** (`Cygwin`, `perl`, `cat`, `sed`, `php` functionality for transforming text, XML and `NDJSON` replaced by Javascript using `R` package `V8`); addresses personally communicated concerns and faciliates use of package `ctrdata` in more environments (e.g., https://github.com/rfhb/ctrdata/issues/26); consequently, this might be a breaking change for analysing certain fields, see above which fields are affected. 

### Other
- added results summary download for CTIS
- added documents download for ISRCTN
- factored out document download function
- ensure `dbFindFields()` returns fields for EU and 3rd country trials in EUCTR (addresses https://github.com/rfhb/ctrdata/issues/26)
- changed order of importing from CTIS into database, improved speed
- better checked data downloads, and repeat them where necessary
- factored out temporary folder creation
- added using `options(ctrdata.tempdir = ...)` if set
- removed `dfListExtractKey()`, long deprecated
- removed `dfMergeTwoVariablesRelevel()`, long deprecated
- reorganised code file layout 
  
# ctrdata 1.15.2 (2023-09-10)

- fix handling as utf8 upstream multi-language strings from CTIS
- correct creating lists for downloading documents for ctis
- adding missing endpoints for CTIS found with increasing amount of data,
  e.g. publicevents.temporaryHaltList.details for 2022-501559-99-00

# ctrdata 1.15.1 (2023-08-29)

- correct LaTeX documentation resulting in CRAN error
- correct parts of downloading from `CTIS`, including file name sanitisation

# ctrdata 1.15.0 (2023-08-27)

- added CTGOV REST API 2.0.0.-test as new register with identifier `CTGOV2`
- handle CTGOV classic interface as register `CTGOV`
- improved `ctrdataURLcopier.js` to only rewrite searches and views from `CTIS`
- mangle CTIS: change `partIIInfo` object into array, adding a new `partIIIinfoKey` so that
  `'{"partIIInfo": "<int>": {...}, "<int>": {...}}'` becomes
  `'{"partIIInfo": [{"partIIIinfoKey": <int>, ...}, {"partIIIinfoKey": <int>, ...}]}')`
- correct dbGetFieldsIntoDf() for specific lists

# ctrdata 1.14.0 (2023-07-16)

- fix `dbFindIdsUniqueTrials()` for single-record register contents
- expand number of CTIS variables that are typed as date
- `dfMergeVariablesRelevel()` superseeds `dfMergeTwoVariablesRelevel()`

# ctrdata 1.13.3 (2023-06-24)

- typo in `dbFindFields()`
- use only CTGOV classic website (ctrdata is being adapted to new website)
- correct missing names and attributes on return vector of `dbFindIdsUniqueTrials()`

# ctrdata 1.13.2 (2023-05-27)

- correct selection of lists with ids for documents to download from CTIS
- reduce dependencies (rvest, dplyr removed)

# ctrdata 1.13.1 (2023-05-07)

- load more CTIS data (publicEvaluation) and download documents
- integrate downloading documents into ctrLoadQueryIntoDb() also for CTGOV
- use documents.path for CTGOV, EUCTR, CTIS; deprecated euctrresultsfilespath
- added documents.regexp to select documents for downloading based on their file name

# ctrdata 1.13.0 (2023-04-23)

- data from CTIS is imported more completely
- adapt other functions to accommodate CTIS
- provide Tampermonkey script to get the URL of a user's query in a register
- speed up `ctrLoadQueryIntoDb()` for CTIS with nodbi >=0.9.2.9000
- keep register names on vector returned by `dbFindIdsUniqueTrials()`
- correct `dbFindFields()` for EUCTR

# ctrdata 1.12.1 (2023-03-29)

- fix escaping hash symbol in PDF rendition of an help page
- fix file encoding for CTIS downloads under MS Windows

# ctrdata 1.12.0 (2023-03-25)

- added first access to new register: CTIS, the EU Clinical Trial Information System
- stop (instead of warning) if register host errors (e.g. incorrect number of records)
- switch to use `curl::multi_download()` which can resume retrievals from registers
- require curl >= 5.0

# ctrdata 1.11.1 (2022-11-20)

- cater for very short EUCTR results-related information
- show warning as beta CTGOV website is not supported
- limit unit testing to MongoDB and SQLite
- return error for ctrGetQueryUrl() if no query URL
- prevent re-using connections to reduce http/2 layer errors
- update query history when querytoupdate was used but no new records found
- make `ctrLoadQueryIntoDb()` to always return visible result
- correct `dfTrials2Long()` identifier (EUCTR no more top "1" across fields)
- correct non-ASCII characters

# ctrdata 1.11.0 (2022-11-02)

- now works with DuckDB (>= v0.6.0) as database backend, using nodbi (>= v0.9.0)
- reduced default number of parallel connections to EUCTR from 10 to 4

# ctrdata 1.10.2 (2022-08-20)

- fix slow speed in `dfName2Value()`
- fix to remove row names from `dfName2Value()`
- fix for internal function to handle tibble
- fix for handling certain ISRCTN queries
- fix `dbGetFieldsIntoDf()` with missing data
- fix timeouts and methods in package testing
- fix `dbGetFieldsIntoDf()` for rare complex fields
- fix URL in Rd file
- make examples runnable with demo database
- include `wherevalue` in `dfName2Value()` result

# ctrdata 1.10.1 (2022-07-24)

- fix documentation issues (https://stat.ethz.ch/pipermail/r-package-devel/2022q3/008240.html)
- fix unit test with unused but missing argument
- fix GitHub actions and tests

# ctrdata 1.10.0 (2022-07-01)

- `ctrLoadQueryIntoDb()` new parameter `euctrresultsfilespath`, deprecating `euctrresultspdfpath`
- `ctrLoadQueryIntoDb()` now also extracts and saves results files other than PDF files
- `ctrFindActiveSubstanceSynonyms()` returns NULL for non-existing active substance

# ctrdata 1.9.1 (2022-04-24)

- type e811... variables
- bugfix in dbGetFieldsIntoDf
- bugfix annotations mix up for some backends
- editorial update vignettes

# ctrdata 1.9.0 (2022-03-13)

- chunked trial batches in `NDJSON` files for accelerated database import
- if package dplyr is loaded, functions return a tibble instead of a data frame
- update and correct documentation
- `dbFindFields()` returns a vector of fields which now has as names the register in which a field occurs
- accelerated binary checks (cygwin / Windows)
- remove internet proxy mangling in order to use system configuration (e.g., transparent proxies used, or environment variable https_proxy specified by user)
- refactored internal caching
- correct `dbGetFieldsIntoDf()` for specific nested data structures
- correct `dfTrials2Long()` for specific fields
- correct `dbFindIdsUniqueTrials()` when only single trial in any register
- modify field typing to decode HTML entities
- type some fields as difftime, e.g. `min_age` in CTGOV
- speed up parts of `dbGetFieldsIntoDf()` and simplify more fields
- `dbFindFields()` returns names of all leaf and node fields
- improve and update documentation
- changed EU Member State to default to DE for dbFindIdsUniqueTrials()
- corrected `installCygwinWindowsDoInstall()` to properly update an installation (remove --prune-install)
- test all binaries after `installCygwinWindowsDoInstall()` and only cache successful binary testing
- correct typing `required_header.download_date`
- improve numbering in `dfTrials2Long()`, covering nested items
- thorough documentation improvement
- simplified `dbFindFields()`
- cleaned up testing binaries
- cleaned up helper scripts
- removed `ctrGetQueryUrlFromBrowser()`, long deprecated
- uses nodbi 0.6.0
- can use PostgreSQL as backend
- include PostgreSQL in Github Actions

# ctrdata 1.8.0 (2021-11-18)

- changes to match nodbi 0.5.0
- simplifying database operations (user-visible functions:
   ctrLoadQueryIntoDb, dbFindIdsUniqueTrials, dbGetFieldsIntoDf),
   without changes to API

# ctrdata 1.7.1 (2021-08-22)

- fix DBI not needed in Imports any more (CRAN Note)
- fix potential file name issue in conversion script
- fix dbFindFields() to never return _id (previously depended on database backend)
- changed tests (not on CRAN detection, register availability, additional tests)

# ctrdata 1.7.0 (2021-07-24)

- much reduced database backend-specific code, using nodbi 0.4.3 (released 2021-07-23)
   which also introduces transactions for sqlite using RSQLite >=2.2.4 (released 2021-03-12)
- temporary directory creation only when needed, more automated deletion
- changes in detecting non-functioning register servers
- further streamlined unit testing

# ctrdata 1.6.0 (2021-05-09)

- added support for ISRCTN
- refactored checking binaries and caching this info
- updated EUCTR download parameters
- refactored ctrGetQueryUrl and ctrOpenSearchPagesInBrowser
- harmonised error checking
- avoid some errors with external scripts
- refactored url / query mangling, added detailed testing
- refactored storing JSON into database (handle big files, reduce memory)
- improved dbFindIdsUniqueTrials (speed, memory, register coverage)
- factored out conversion to JSON
- accelerated EUCTR results and history download and storage
- external scripts now create multiple chunks of records
- use further identifier fields with dbFindIdsUniqueTrials
- adding user info which field entries could not be typed

# ctrdata 1.5.3 (2021-04-19)

- include message how to handle server certificate issues,
   by propagating user settings for httr to curl operations
- ensure identical return structures when no new trials found
- dfTrials2Long: harmonise identifier level assignment,
   address cases where field occurs only once in input df
- dfMergeTwoVariablesRelevel: corrected and improved user info
- dfName2Value: remove duplicate rows, e.g. from duplicated criteria

# ctrdata 1.5.2 (2021-04-05)

- bugfix of EOL for converting EUCTR files

# ctrdata 1.5.1 (2021-03-21)

- bugfix for non-matching euctr protocol and result ids:
   any trials from EUCTR for which results were downloaded with
   version 1.5.0 should be downloaded again (ctrLoadQueryIntoDb)
- dfTrials2Long refactored and accelerated
- API change: dfTrials2Long return value (identifier replaces main_id and sub_id)
- new option to save EUCTR results PDF files in user-specified directory

# ctrdata 1.5.0 (2021-03-14)

- return values of dbGetFieldsIntoDf are now mostly
   identical whether using src_mongo or src_sqlite,
   to best ensure portability of analysis code
- permit dots in queries / URLs
- improved handling of queryterm
- renamed ctrGetQueryUrlFromBrowser to ctrGetQueryUrl
- soft deprecated ctrGetQueryUrlFromBrowser
- ensure parallel retrievals from EUCTR
- speed up routines in dbGetFieldsIntoDf
- make dfTrials2Long handle NA better
- improved documentation, clarified examples
- simplified internals for typing fields, start typing results fields

# ctrdata 1.4.1 (2020-11-03)

- reset row names on data frames returned by functions
- update curl parameters when accessing EUCTR

# ctrdata 1.4 (2020-10-17)

- new: easy access to variables with
   dfTrials2Long() + dfName2Value()
- improved dfMergeTwoVariablesRelevel()
   to maintain type of data
- revised and simplified vignettes
- deprecated: dfListExtractKey()
- refactored parts of euctr retrieval
- notify user when euctr register server does not permit compression and how long retrieval will take
- fixed identifying unique ids

# ctrdata 1.3.2 (2020-10-03)

- quote system file paths

# ctrdata 1.3.1 (2020-08-01)

- fix error in CI tests

# ctrdata 1.3.0 (2020-07-27)

- workaround EUCTR certificate issue
- streamline ctrGetQueryUrlFromBrowser()
- better handling of complex fields
- include further tests for query string handling, checking more parameters and return values
- better clean-up after testing
- ctrLoadQueryIntoDb(querytorerun = ...) now looks for the date when the querytorerun was last run, to more often use euctr update options
- switching from travis to github action
- upped coverage of code tested

# ctrdata 1.2.1 (2020-05-18)

- tinytest >= 1.2.1 to avoid regression error
- correct testing detail

# ctrdata 1.2 (2019-12-07)

- correct cygwin install detail

# ctrdata 1.1 (2019-11-12)

- release after nodbi 0.4 is available
- update description for installation from github
- handled mixed arrays and text values in same key of ctgov trial records
- more user information during importing
- further nesting added for euctr trial records
- user verbose information extended for record importing
- improved parsing of euctr trial records
- correct re-opening of sqlite connection

# ctrdata 1.0.1 (2019-10-22)

- correction of testing

# ctrdata 1.0 (2019-10-16)

- switch to nodbi::scr_{mongo,sqlite}() with re-implementation of most functions
- switch from testthat to tinytest, so that users can check with tinytest::test_package("ctrdata")
- improvements to euctr trial import  
- new function dfListExtractKey
- speed up testing bash commands under windows

# ctrdata 0.18.2 (2019-04-30)

- extended compatibility with cygwin and Windows
- find and use any cygw* under windows
- refactored escaping bash command when called under windows
- corrected typing date fields

# ctrdata 0.18.1 (2019-04-14)

- simplified cygwin install
- updated documentation
- corrected inconsistent handling of query terms
- added automated proxy handling

# ctrdata 0.18 (2019-04-11)

- release version
- bug fixes in field typing
- move to use remote mongodb server
- updated vignettes

# ctrdata 0.17 (2019-03-27)

- improve dbFindFields() formatting
- added parameter to force running a query again
- added further typing (some of the numeric fields)
- improve cygwin install attempts and information
- removed dependency on local mongodb installation (major rewrite)
- improved support for remote mongodb servers (note changes in host / db / uri parameters)
- Important: Added no checking of SSL certificates for EUCTR because the EUCTR server is
   not sending the required intermediate and root certificates, thus failing curl and httr, see
   https://www.digicert.com/help/?host=www.clinicaltrialsregister.eu
- fixed EUCTR results retrieval (curl return value order not predictable)
- removed second time adding metadata in one function
- streamlined user information and progress feedback

# ctrdata 0.14.3 (2019-03-12)

- turned error into message when no new trials are found
- prevent failing tests if no new trials found in rss feed

# ctrdata 0.14.2 (2019-03-07)

- harmonise user information

# ctrdata 0.14.1 (2019-03-07)

- replaced RCurl (which failed for some register servers) by httr and curl
- create README.md from README.Rmd

# ctrdata 0.14 (2019-03-06)

- intention to submit to CRAN, therefore changing several warnings to messages, improve testing of tool chain applications

# ctrdata 0.13.3 (2019-03-03)

- prettified dbFindFields() by removing count symbols (XX.) from paths
- improve converting of invalid XML from EUCTR result files to JSON

# ctrdata 0.13.2 (2019-02-28)

- made EUCTR retrieval more robust
- added marginal case for url of single trial in EUCTR
- extended timeout for checking online status of EUCTR

# ctrdata 0.13.1 (2019-02-24)

- added typing of dates and some logical fields when using dbGetFieldsIntoDf()

# ctrdata 0.13 (2019-01-06)

- dbGetVariablesIntoDf() is deprecated, use dbGetFieldsIntoDf() instead
- dbFindVariable() is deprecated, use dbFindFields() instead
- in dbMergeTwoVariablesRelevel() parameter varnames is deprecated, use colnames instead

# ctrdata 0.12.1 (2018-12-15)

- added function ctrFindActiveSubstanceSynonyms() to obtain synonyms for an active substance
- added user information on number of trials in CTGOV to be downloaded, and limit this to 5000 per query
- corrected import from EUCTR for details = FALSE

# ctrdata 0.12 (2018-05-19)

- added possibility to add user's annotations to records retrieved with a query (new option annotate.text)

# ctrdata 0.11.2 (2018-04-22)

- changed queryterm processing

# ctrdata 0.11.1 (2018-04-07)

- improved installFindMongoBinaries(),
   should now better detect mongo binary locations and use
   for example in cron scripts, which may not have access
   to a user's path information

# ctrdata 0.11 (2018-01-28)

- newly retrieved: EUCTR results history, into new fields
   "firstreceived_results_date" and "version_results_history"
- adding feature as per issue #8

# ctrdata 0.10.4 (2017-12-28)

- note on compatibility with mongoDB versions
- fixing issue #8
- simplified license

## ctrdata 0.10.3 (2017-11-24)

- changed custom-built "x5_trial_status" to "p_end_of_trial_status" provided by EUCTR

# ctrdata 0.10.2 (2017-11-22)

- editorial project updates

# ctrdata 0.10.1 (2017-07-30)

- now loading results from euctr where available as xml

# ctrdata 0.10.0 (2017-07-25)

- fully load results from ctgov
- prepare loading results from euctr

# ctrdata 0.9.14 (2017-06-28)

- refactored system calls
- windows now part of continuous integration

# ctrdata 0.9.13 (2017-06-23)

- refactored ctrLoadQueryIntoDb

# ctrdata 0.9.12 (2017-06-18)

- Preparing for new CTGOV interface
- Improved documentation
- Corrected ctrGetQueryUrlFromBrowser return value

# ctrdata 0.9.11.1 (2017-02-04)

- Improved documentation

# ctrdata 0.9.11 (2017-01-15)

- Added functionality: EUCTR fallback import mechanism if large JSON file fails to import into mongoDB (by splitting and importing one JSON file for each trial, tested with several thousand trials)

# ctrdata 0.9.10.1 (2017-01-12)

- Fixes issues with conversion of EUCTR records that did not have details.
- Fixes issue that placebo information was converted into IMP fields.

# ctrdata 0.9.10.0 (2016-12-28)

- Added metadata attributes to returned objects to indicate database, query, timestamp etc.

# ctrdata 0.9.9.5 (2016-12-14)

- Added option ctrLoadQueryIntoDb(querytoupdate = "last") to re-download last query in collection

# ctrdata 0.9.9.4 (2016-11-18)

- Added progress indicator to ctrLoadQueryIntoDb() to indicate network download traffic

# ctrdata 0.9.9.3 (2016-11-17)

- deduplication in dbFindIdsUniqueTrials() optimised for speed and memory, added check by ISRCTN

# ctrdata 0.9.9.2 (2016-11-13)

- corrected deduplication in dbFindIdsUniqueTrials()

# ctrdata 0.9.9.1 (2016-11-12)

- renamed ctrQueryHistoryInDb() to dbQueryHistory()
- note: change in json format of query history, breaking compatibility
- refactored all concerned functions to use mongolite
- rmongodb is no more supported

# ctrdata 0.9 (2016-10-17)

- changed implementation of dbFindIdsUniqueTrials()
- editorial changes to examples

# ctrdata 0.8.1 (2016-09-07)

- added field to indicate source register
- improved ctrLoadQueryIntoDb() with details = FALSE
- added example for map plotting

# ctrdata 0.8 (2016-09-04)

- dbFindIdsUniqueTrials now encapsulates dfFindIdsUniqueEuctrRecord
- dfFindIdsUniqueEuctrRecords removed
- installation instructions updated after recently rmongodb was removed from CRAN

# ctrdata 0.7 (2016-05-29)

- dbGetVariablesIntoDf changed to concatenate values in array and objects
- completed test adaptation for travis
- improving perl regex
- checking helper applications

# ctrdata 0.6.2 (2016-04-20)

- add / update field "record_last_import" for every imported / updated record

# ctrdata 0.6.1 (2016-04-02)

- changed to provide vignettes

# ctrdata 0.6 (2016-02-25)

- different update mechanism for EUCTR implemented
- corrected function name from db... to dfFindUniqueEuctrRecord()

# ctrdata 0.5.9 (2016-01-23)

- Corrected bugs
- Started preparation of submission to CRAN
- Preparing to include package unit tests

# ctrdata 0.5 (2015-11-29)

- Published on github
- Improved documentation

# ctrdata 0.4 (2015-10-08)

- Renamed all functions for consistency and ease-of-use

# ctrdata 0.3 (2015-10-06)

- Added functionality to download xml data from CTGOV, which includes more data than the csv format

# ctrdata 0.2.8

- Changed and extended how history of queries is included in database.
- New function dbCTRQueryHistory()

# ctrdata 0.2.7

- Added function for merging variables such as from different registers and optionally to merge values into new values
- Note that function findCTRkey was renamed to dbFindCTRkey because it acts on the database

# ctrdata 0.2.5

- Added function for selecting preferred language versions of trials from EUCTR
- Improved use of automatic proxy configuration script

# ctrdata 0.2.2

- Added proxy function and improved installation of cygwin under MS Windows

# ctrdata 0.2 (2015-09-19)

- Now also working on MS Windows

# ctrdata 0.1 (2015-09-15)

- First version with basic functionality
- Limited testing
- Works on Mac OS X (10.10.x)
