Implementation of several phenotype-based family genetic risk scores
with unified input data and data preparation functions to help facilitate
the required data preparation and management. The implemented family genetic
risk scores are the extended liability threshold model conditional on family history (LT-FH++)
from Pedersen (2022) <doi:10.1016/j.ajhg.2022.01.009> and Pedersen (2023) <https://www.nature.com/articles/s41467-023-41210-z>,
Pearson-Aitken Family Genetic Risk Scores (PA-FGRS) from Krebs (2024) <doi:10.1016/j.ajhg.2024.09.009>,
and family genetic risk score by Kendler (2021) <doi:10.1001/jamapsychiatry.2021.0336>.
| Version: |
1.0.0 |
| Imports: |
batchmeans, dplyr, future.apply, future, lubridate, purrr, Rcpp, rlang, stats, stringr, tibble, tmvtnorm, tidyselect, igraph, xgboost, tidyr |
| LinkingTo: |
Rcpp |
| Suggests: |
knitr, rmarkdown, testthat (≥ 3.0.0), MASS |
| Published: |
2025-07-07 |
| DOI: |
10.32614/CRAN.package.LTFGRS |
| Author: |
Emil Michael Pedersen [aut, cre],
Jette Steinbach [aut],
Lucas Rasmussen [ctb],
Morten Dybdahl Krebs [aut] |
| Maintainer: |
Emil Michael Pedersen <emp at ph.au.dk> |
| BugReports: |
https://github.com/EmilMiP/LTFGRS/issues |
| License: |
GPL (≥ 3) |
| URL: |
https://emilmip.github.io/LTFGRS/ |
| NeedsCompilation: |
yes |
| Language: |
en-GB |
| Materials: |
README NEWS |
| CRAN checks: |
LTFGRS results [issues need fixing before 2025-07-21] |